ANALOGUES OF NONICEPTINE AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF

摘要

FIELD: organic chemistry, pharmacy.;SUBSTANCE: invention relates to new biologically active compounds that are able to modulate the pharmacological response of one or some opioid receptors taken among ORL-1 and -receptors. Invention describes a compound of the formula (I): wherein W represents hydrogen atom, (C₁-C₁₀)-alkyl, (C₁-C₄)-alkyl-SO₂N(V₁)₂, cyano-(C₁-C₁₀)-alkyl, (C₁-C₄)-alkyl-CON(V₁)₂, -NH₂-SO₂-(C₁-C₄)-alkyl-, (C₁-C₄)-alkyl-COOV₁ wherein all V₁ represent (C₁-C₆)-alkyl; Q represents a 6-membered aromatic group; n represents a whole number from 0 to 3; n' represents a whole number 0 or 1; A, B and C represent hydrogen atom; Z is taken among the group including a bond, linear or branched (C₁-C₆)-alkylene; R₁ is taken among the group including hydrogen atom, (C₁-C₁₀)-alkyl, (C₃-C₁₂)-cycloalkyl, (C₂-C₁₀)-alkylene, (C₃-C₁₂)-cycloalkylamino-group, benzyl, (C₃-C₁₂)-cycloalkenyl, monocyclic, bicyclic or tricyclic aryl wherein indicated alkyl, cycloalkyl, alkenyl, (C₃-C₁₂)-cycloalkylamino-group or benzyl are optionally substituted with substitutes taken among the group including (C₁-C₁₀)-alkyl, phenyl, benzyl, benzyloxy-group wherein indicated phenyl, benzyl and benzyloxy-group are substituted optionally with (C₁-C₁₀)-alkyl and indicated (C₃-C₁₂)-cycloalkyl, (C₃-C₁₂)-cycloalkenyl, monocyclic, bicyclic or tricyclic aryl are substituted optionally with 1-3 substitutes taken among the group including (C₁-C₁₀)-alkyl and benzyl wherein indicated benzyl is substituted optionally with (C₁-C₁₀)-alkyl; R₂ represents hydrogen atom and under condition that when n' = 0 then ZR₁ doesn't means hydrogen atom (H), or to its pharmaceutically acceptable salt or solvate. Also, the invention describes a pharmaceutical composition based on thereof. Invention provides preparing new compounds possessing the useful biological properties.;EFFECT: valuable medicinal properties of compounds and pharmaceutical composition.;21 cl, 5 tbl, 8 ex