USING DERIVATIVES OF (-)-(3-TRIHALOMETHYLPHENOXY)-(4-HALOPHENYL)-ACETIC ACID IN TREATMENT OF RESISTANCE TO INSULIN, DIABETES MELLITUS TYPE II, HYPERLIPIDEMIA AND HYPERURICEMIA

摘要

FIELD: organic chemistry, medicine, endocrinology.;SUBSTANCE: invention relates to improved methods for modulation of diabetes mellitus type II in mammal and modulation of resistance to insulin. Methods involve administration to indicated mammal needing in this treatment of (-)-stereoisomer of compound of the formula (I): wherein R is chosen from group including hydroxy-, lower araloxy-, d-(lower)-alkylamino-(lower)-alkoxy-, (lower)-alkylamido-(lower)-alkoxy-, benzamido-(lower)-alkoxy-, ureido-(lower)-alkoxy-, N'-(lower)-alkyl-ureido-(lower)-alkoxy-, carbamoyl-(lower)-alkoxy-, halophenoxy-substituted lower alkoxy-, carbamoyl-substituted phenoxy-group; or R represents hydrolysable ester group; each X represents independently halogen atom; or its pharmaceutically acceptable salt wherein (-)-stereoisomer doesn't comprise conceptually (+)-stereoisomer. Also, invention relates to pharmaceutical compositions comprising (-)-stereoisomer of compound of the formula (I) and wherein compositions show significantly reduced inhibitory effect on activity of cytochrome P-450 2C9 as compared with racemic composition having 0% enantiomeric excess of (-)-stereoisomer.;EFFECT: valuable medicinal properties of compound and pharmaceutical composition, improved preparing methods.;59 cl, 21 dwg, 8 tbl, 18 ex