METHOD FOR OBTAINING INACTIVATED VACCINE AGAINST VIBRIOSIS IN FISH

摘要

FIELD: biotechnology.;SUBSTANCE: the present innovation deals with obtaining certain broods of Vibrio anguillarum strains upon nutritive medium followed by their mixing, cultivating in fermenter, inactivation of grown culture with formalin and packaging. As strains of Vibrio anguillarum it is necessary to apply the strain of Vibrio anguillarum N2 and that of Vibrio anguillarum VUR-19 the broods of which should be mixed at equal ratio. Packaging of vaccine should be fulfilled at concentration of microbial cells being 80-100 bln/ml nutritive medium. The innovation enables to obtain vaccine of high prophylactic and curative activity.;EFFECT: higher efficiency.;4 cl, 1 dwg, 2 ex