A method for the production of micro spherical crystallites manufactured according to the microspherical crystallites and their use

摘要

The invention relates to a method for producing microspherical crystallites with a uniform spherical shape and an extremely narrow size distribution. Said crystallites consist wholly or partially of a linear water-insoluble polysaccharide, preferably of 1,4-alpha-D-polyglucane, have a degree of crystallinity of 80% and can contain additional polymers and/or active ingredients, which are in particular biodegradable. They are particularly suitable for the controlled release of active ingredients. They are produced by fusing 1,4-alpha-D-polyglucane or the polysaccharide in water, introducing the fusion into a precipitant, cooling the mixture and separating the particles that have formed.