Metal complexes based on tetrathiol ligands and their application in nuclear medicine diagnostics and endoradione nuclide therapy as well as processes for the preparation of metal complexes

摘要

The object of the invention is to propose radiolytic and metabolically stable metal complexes which are suitable for conjugation with biomolecules, and to provide a process for their preparation. DOLLAR A The solution includes metal complexes based on tetrathiol ligands of the formula DOLLAR F1 wherein DOLLAR A (CH-R * 1) represents substituted or unsubstituted methylene bridges and DOLLAR AR * 1 * H, substituted or unsubstituted alkyl groups or substituted or unsubstituted aryl groups, m and n represent the number of methyl groups, the sum of m and n is between 4 and 10, DOLLAR AR · 2 · for H, OR · 1 · or NHR · 1 ·, DOLLAR AY 4 times H , 99m TcO, 186 ReO, 188 ReO, 99m TcN, 186 ReN or 188 ReN, DOLLAR AX for (CH) ¶2¶, the unsubstituted amino group (NH) or substituted Amino group (NZ), the guanidyl unit DOLLAR F2 or the urea group DOLLAR F3, DOLLAR A wherein DOLLAR AZ - (CH-R · 1 ·) -A means, p is the number of methylene groups and is between 2 and 8, DOLLAR AA represents a linkable unit, such as COOH, COR · 3 ·, -NCS and DOLLAR AR · 3 · fü r OH, OR · 1 · or NHR · 1 ·, DOLLAR A and the use of the metal complexes according to claim 1 for nuclear medical diagnostics and endoradione nuclide therapy. DOLLAR A In addition, a process for the preparation of the metal complexes is given.