TETRATHIOL LIGANDS, METAL COMPLEXES, CONJUGATES, AND KITS, THE USE THEREOF IN NUCLEAR MEDICINE DIAGNOSTICS AND ENDORADIONUCLIDE THERAPY, AND METHOD FOR PRODUCING THE TETRATHIOL LIGANDS AND METAL COMPLEXES

摘要

The invention relates to a ligand of formula (I), where (CH-R1) and (CH-R1') are substituted or non-substituted methylene bridges; the individual R1 and R1', and R3 and R3', are each selected independently of each other from hydrogen, substituted or non-substituted alkyl groups, substituted or non-substituted aryl groups; and m and n are positive whole numbers, where m represents the number of (CH-R1') groups and n represents the number of (CH-R1) groups; wherein the sum of m and n is in the range from 4 to 10; R2 and R2' are selected independently of each other from hydrogen, substituted or non-substituted alkyl groups, substituted or non-substituted carboxyl groups, substituted or non-substituted aryl groups, or Z; X is a substituted or non-substituted methylene bridge having the formula CHR4 or a non-substituted amino group (N-H) or substituted amino group (N-Z); wherein Z stands for –(CH-R5)p-A, where (CH-R5) represents a substituted or non-substituted methylene bridge, and p is a whole number standing for the number of the (CH-R5) groups, wherein p is in the range from 2 through 8; A represents a linkable unit, wherein R4 and the individual R5 are each selected independently of each other from hydrogen, substituted or non-substituted alkyl groups, substituted or non-substituted aryl groups.