Use of 2,4-dihydroxy-3-methylbenzoate derivatives for preparing medicaments or as basic substance for the development of other agents used for treating benign prostate hyperplasia, prostate carcinoma or spinobulbar muscular atrophy

摘要

Use of 2,4-dihydroxy-3-methylbenzoate derivatives (I) for preparing medicaments or as basic substance for the development of other agents used for treating benign prostate hyperplasia, prostate carcinoma or spinobulbar muscular atrophy. Use of 2,4-dihydroxy-3-methylbenzoate derivatives of formula (I) for preparing medicaments or as basic substance for the development of other agents used for treating benign prostate hyperplasia, prostate carcinoma or spinobulbar muscular atrophy. R 11-4C alkyl; and R 2H, CH 3, ethyl or propyl. Independent claims are included for: (1) a medicament for treating benign prostate hyperplasia, prostate carcinoma or spinobulbar muscular atrophy, comprising (I); (2) (I) (where R 1 is iso-propyl, geranyl or ethylbenzol sulfonamide); (3) a method for the isolation of atraric acid from biological material comprises crushing biological material, extracting biological material with a solvent, which is monovalent 1-4C alcohol or volatile, (partly)-halogenated 1C-hydrocarbon, fractionating the extract and isolating atraric acid from the biological material containing fraction; and (4) a method for the preparation of atraric acid derivatives comprising stirring the atraric together with an equimolar amount of alkali hydroxide or alkaline-earth hydroxide in a solution of a primary aliphatic alcohol and isolating the atraric acid derivatives from the reaction mixture. [Image] ACTIVITY : Muscular-Gen.; Cytostatic. MECHANISM OF ACTION : Estrogen receptor agonist.