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A process for the preparation of a tray with a controlled release with the use of a pore-forming agent in the coating
A process for the preparation of a tray with a controlled release with the use of a pore-forming agent in the coating
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机译:一种在包衣中使用成孔剂制备具有可控释放的托盘的方法
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摘要
The invention concerns a method for producing a controlled-release pharmaceutical preparation with a particle-containing coating, the coating being derived from an aqueous dispersion of a film-forming water insoluble polymer and a water soluble pore-forming agent. By suspending, instead of dissolving the pore-forming agent, the resulting coating will contain particles of the pore-formers with a predetermined size that creates, when disintegrated or dissolved in the body fluid, canals or a network of pores through the polymer film. Due to this network, the film will get a good mechanical stability and are left intact after the release of the drug.
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