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PROCESS FOR THE INHIBITION OF AMYLOID PROTEIN AGGREGATION AND FOR THE DIAGNOSTIC DETECTION OF AMYLOID DEPOSITION USING AMINO INDIGENOUS DERIVATIVES
PROCESS FOR THE INHIBITION OF AMYLOID PROTEIN AGGREGATION AND FOR THE DIAGNOSTIC DETECTION OF AMYLOID DEPOSITION USING AMINO INDIGENOUS DERIVATIVES
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机译:氨基酸自体衍生物抑制淀粉样蛋白凝集和诊断淀粉样沉积的方法
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摘要
The present invention provides compounds of Formula (I) and a method of treating Alzheimer's disease using a compound of Formula (I), wherein: RSUP1 /SUPand RSUP2 /SUPinclude alkyl and phenylalkyl; RSUP3 /SUPis hydrogen or alkyl; and RSUB4 /SUBand RSUB5 /SUBinclude alkyl, alkoxy, carboxyl, alkoxycarbonyl, and nitro. Also provided is a method of inhibiting the aggregation of amyloid proteins using a compound of Formula (I) and a method of imaging amyloid deposits using compounds of Formula (I).
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机译:本发明提供了式(I)化合物和使用式(I)化合物治疗阿尔茨海默氏病的方法,其中:R 1 SUP>和R 2 SUP>包括烷基和苯烷基; R 3 SUP>是氢或烷基; R 4 SUB>和R 5 SUB>包括烷基,烷氧基,羧基,烷氧基羰基和硝基。还提供了使用式(I)的化合物抑制淀粉状蛋白的聚集的方法和使用式(I)的化合物使淀粉状蛋白沉积物成像的方法。
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