Targeting amyloid precursor protein shuttling and processing-long before amyloid beta formation

摘要

Targeting early steps in amyloid-beta production:Alzheimer’s disease(AD)has a long history as the'amyloid deposit'disorder.Many disorders are now known to be caused by proteinβ-sheet misfolding and aggregation(e.g.,Parkinson’s disease:α-synuclein;Huntington’s disease:Huntingtin;