use of piperazine phenothiazine derivatives in the manufacture of a medicinal product, with a neuroprotektiven and / or neurotropischen effects on the central nervous system and / or pns

摘要

In the manufacture of medicament for treating central and peripheral neurodegenerative disorders, piperazine phenothiazine derivatives or their salts or esters having neuroprotector and/or neurotrophic effects on central nervous system (CNS) and peripheral nervous system (PNS) are used. ACTIVITY : Neuroprotective; Antiparkinsonian; Nootropic. Fluphenazine N-Mustard dihydrochloride (a) was tested for Neuroprotective activity. Cortical and spinal cord neurons were isolated from 15 - 17 days old foetuses of female Wistar rates and cultured in neurobasal/B27 medium until cell differentiation. Cell cultures were incubated with (a) (100 nmol/l) and were compared to cell cultures incubated alone only with brain derived neurotrophic factor (50 Microg). Neuronal survival was then monitored at 24, 72 and 120 hours, by counting the number of cells. The ratio of (a)/control were: at 24 hours = 0.98/1; at 72 hours = =1.25/1.2; and at 120 hours = 1.6/ 1.5 respectively. MECHANISM OF ACTION : None given.