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UNLOADED MORPHOLIN-BASED POLYMERS WITH CHIRAL, PHOSPHOROUS BRIDGES BETWEEN THE SUB-UNITS
UNLOADED MORPHOLIN-BASED POLYMERS WITH CHIRAL, PHOSPHOROUS BRIDGES BETWEEN THE SUB-UNITS
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机译:子单元之间带有手性,磷桥的,以吗啉为基础的聚合物
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摘要
A polymer composition is disclosed composed of morpholino subunit structures linked together by uncharged, phosphorus-containing chiral linkages, one to three atoms in length. These chiral linkages join the morpholino nitrogen of one subunit to the 5' exocyclic carbon of an adjacent subunit. Each subunit contains a purine or pyrimidine base-pairing moiety effective to bind by hydrogen bonding to a specific base or base-pair in a target polynucleotide.
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