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METHOD FOR RADIOLABELING A SOMATOSTATIN PEPTIDE ANALOG CONTAINING A DISULFIDE BINDING WITH A RADIOISOTOP OF THE RHENIUM AND ITS THERAPEUTIC APPLICATIONS
METHOD FOR RADIOLABELING A SOMATOSTATIN PEPTIDE ANALOG CONTAINING A DISULFIDE BINDING WITH A RADIOISOTOP OF THE RHENIUM AND ITS THERAPEUTIC APPLICATIONS
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机译:含放射性同位素的DIS二硫键结合的生长抑素肽类似物的放射标记方法及其治疗应用
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摘要
The invention relates to radiotherapy with somatostatin-derived peptides labeled with medically useful metal ions. The invention in particular provides for methods and reagents for labeling somatostatin-derived peptides with perrhenate, in which a solution including somatostatin-derived peptide analogue containing at least one disulfide bond is provided, the solution is reacted with stannous ions and with a radioisotope, wherein the stannous ions are sufficient to substantially reduce the disulfide bonds of the peptide and the radioisotope, and the radiolabeled somatostatin-derived peptide analogue recovered. Also provided are methods for regional administration of radiolabeled somatostatin-derived peptides, methods for enhanced regional retention of radiolabeled somatostatin-derived peptides, methods for treatment of arthritis using radiolabeled somatostatin derived peptides, and methods for stabilizing radiolabeled somatostatin derived peptides.
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