O2-ARYLATE OR O2 GLYCOSYIATE 1-SUBSTITUTED DIAZEN-1-IUM-1,2-DIOLATE AND O2-SUBSTITUTED 1 (2-CARBOXYLATE) PYROLIDIN-1-YL DIAZEN-1-IUM-1,2-DIOLATE

摘要

O 2 -Substituted 1-[(2-carboxylato)pyrrolidin-1-yl] diazeniumdiolates are stable in aqueous solution and, in many cases, they can be activated for NO release by enzymatic action. Furthermore, if an N-nitroso derivative is formed by net formal cleavage of the N-N double bond of the 1-[(2-carboxylato)pyrrolin-1-yl]diazen-1-ium-1,2-diolate, the N-nitroso compound is noncarcinogenic. Such compounds are believed to be particularly useful in the treatment of fulminant liver failure, malaria, respiratory problems, impotence, and a variety of cardiovascular/hematologic disorders.