O2-arylated or O2-glycosylated 1-substituted diazen-1-ium-1,2-diolates and O2-substituted 1-(2-carboxylato) pyrrolidin-1-yl diazen-1-ium-1,2-diolates

摘要

Diazeniumdiolates, wherein the N¹ position is substituted by an inorganic or organic moiety and the O²-oxygen is bound to a substituted or unsubstituted aromatic group, are provided. Also provided are O²-glycosylated 1-substituted diazen-1-ium-1,2-diolates (O²-glycosylated diazeniumdiolates) and O²-substituted 1-(2-carboxylato)pyrrolidin-1-yldiazen-1-ium-1,2-diolates (1-(2-carboxylato)pyrrolidin-1-yldiazeniumdiolates). The O²-aryl diazeniumdiolates are stable with respect to the hydrolytic generation of nitric oxide in neutral to acidic solutions and generate nitric oxide in basic or nucleophilic environments or microenvironments. Also provided are compositions, including pharmaceutical compositions, comprising such compounds and methods of using such compounds.