PROCESS FOR THE PREPARATION OF PROLONGED RELEASE COMPOSITIONS AND USE THEREOF FOR THE TREATMENT OF CHRONIC AFFECTIONS OF THE CENTRAL NERVOUS SYSTEM (CNS)

摘要

Process for the preparation of microspheres comprising poly (D, L-lactide-co-glycolide), poly (D, L-lactide (PLAGA or PLA) or their mixtures, soluble in ethyl acetate, encapsulating at least one active substance insoluble in ethyl acetate Compositions comprising the microspheres homogeneously dispersed in a solution of biocompatible polymer (s) capable of forming a gel in situ, after administration across the blood barrier meningeal (BHM), for the treatment of chronic CNS conditions.