PROCESS FOR THE PREPARATION OF PROLONGED RELEASE COMPOSITIONS AND USE THEREOF FOR THE TREATMENT OF CHRONIC AFFECTIONS OF THE CENTRAL NERVOUS SYSTEM (CNS)

摘要

The inventive method for preparing microspheres comprising poly (D,L-lactide-co-glycolide), poly(D,L-lactide (PLAGA or PLA)) or the mixtures thereof which are ethyl acetate soluble and encapsulate at least one type of ethyl acetate non-soluble active substance. Compositions containing microspheres homogeneously dispersed in a biocompatible polymer solution capable to form a gel in situ after administration through a haemo-meningeal barrier (HMB) for treating CNS chronic diseases are also disclosed.