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METHOD FOR DETECTING INTERACTIONS BETWEEN A G PROTEIN-COUPLED RECEPTOR (GPCR) AND ONE OF THE GALPHA OR GALPHA / GAMMA SUBUNITS OF A G PROTEIN
METHOD FOR DETECTING INTERACTIONS BETWEEN A G PROTEIN-COUPLED RECEPTOR (GPCR) AND ONE OF THE GALPHA OR GALPHA / GAMMA SUBUNITS OF A G PROTEIN
The present invention relates to a method for detecting G-protein-coupled receptor-specific ligands (agonists or antagonists) (GPC), which comprises the steps of: 1) contacting a labeled receptor with a member of a donor / acceptor pair with a Galpha or Gbetagamma subunit of a G protein labeled with the other member of the donor / acceptor pair, and 2) measuring proximity transfer between the donor and the acceptor.Application: Screening of new drugs.
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