PHARMACEUTICAL METHOD, DOSING REGIMES AND DOSAGE FORM FOR THE TREATMENT OF ALZHEIMER'S DISEASE

摘要

PPROBLEM TO BE SOLVED: To provide a more effective and safe medicament for treatment of AD. PSOLUTION: In general, the invention relates to a pharmaceutical dose having R-flurbiprofen as an active ingredient that upon oral administration of a single dose to a fasting subject provides a CSBmax/SBof about 30-95 g per mL. When the dose is administered to an individual having mild-to-moderate Alzheimer's disease (or desiring protection against Alzheimer's disease) twice daily for at least 4 months according to guidelines, an improvement or lessening in decline of cognitive function as characterized by cognition tests is observed in the patient. The composition of the invention is formulated with one or more pharmaceutically acceptable excipients, salts or carriers. PCOPYRIGHT: (C)2008,JPO&INPIT