METHOD FOR STABILIZING SIROLIMUS DERIVATIVE OR PACLITAXEL

摘要

PROBLEM TO BE SOLVED: To stabilize a sirolimus derivative or paclitaxel by preventing its deterioration/degradation, to prolong the effective period of the medicine or a pharmaceutical product mixed with the medicine, to keep a medicine stable until the medicine is eluted and to improve its effectiveness in a sustained-release preparation or a medicine-release type intracorporeal implant structure.;SOLUTION: The method for stabilizing a sirolimus derivative or paclitaxel comprises dissolving edaravone, a sirolimus derivative or paclitaxel and another additive to be added, if necessary, in a solvent such as ethanol or tetrahydrofuran or suspending them in a solvent to give a solution or a slurry, optically distilling away the solvent and drying the resultant substance to give an edaravone-containing sirolimus derivative or an edaravone-containing paclitaxel.;COPYRIGHT: (C)2007,JPO&INPIT