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PRENATAL SCREENING FOR DOWN'S SYNDROME USING HYPERGLYCOSYLATED GONADOTROPIN
PRENATAL SCREENING FOR DOWN'S SYNDROME USING HYPERGLYCOSYLATED GONADOTROPIN
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机译:高糖基性腺嘌呤对唐氏综合征的产前检查
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摘要
PROBLEM TO BE SOLVED: To provide a specimen for screening-testing the presence of a Down's syndrome of a fetus of a gravida comprising a hyperglycosylated gonadotropin.;SOLUTION: The hyperglycosylated gonadotropin comprises a variant population of chorionic gonadotropin, a chorionic gonadotropin-free β-subunit, a β-core fragment, and/or α-subunit, and those are difference in a carbohydrate content from one observed in a sample obtained from the gravida carrying the normal fetus. The presence of the Down's syndrome is indicated in the fetus of the woman by qualitative or quantitative observation of a difference in the carbohydrate content of the hyperglycosylated gonadotropin population from a control sample containing a normal gonadotropin population, or by direct observation of the variant species appearing in the Down's syndrome. A typical screen test includes carbohydrate analysis, immunoassay, or a combination thereof. For example, the screen test uses concanavalin A reactive to the carbohydrate moiety, and an antibody to a hyperglycosylated species.;COPYRIGHT: (C)2007,JPO&INPIT
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