Alzheimer's disease-induced transgenic mice expressing mutant βCTF99

摘要

Relates to Alzheimer's disease induced transgenic animals, and more particularly, animal transformation vector, containing the C-terminal sections of mutant human amyloid beta protein with (βCTF99) Indiana mutations, and the present invention, this fertilized egg Alzheimer's disease induces on transgenic mice were produced by transplanting the nucleus of. Transgenic mice of the present invention, was Genwa decrease of memory and cognitive ability, the clinical symptoms of Alzheimer's disease, such as increased anxiety. Thus, transgenic mice of the present invention can be a animal model for studying Alzheimer's disease. In particular, the transgenic mice of the present invention, for reveal an increase in the sense of insecurity significantly, it can be used as a disease for animal models related to a sense of insecurity than transgenic animal models of other aspects of Alzheimer's disease known in the art.