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Classification of acute myeloid leukemia by gene expression profiling, diagnosis, prognosis and
Classification of acute myeloid leukemia by gene expression profiling, diagnosis, prognosis and
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机译:通过基因表达谱分析,诊断,预后和分类对急性髓细胞性白血病进行分类
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摘要
The present invention relates to methods of genetic analysis for the classification, diagnosis and prognosis of acute myeloid leukemia (AML). The invention provides a method for producing a classification scheme for AML comprising the steps of a) providing a plurality of reference samples, the reference samples comprising cell samples from a plurality of reference subjects affected by AML; b) providing reference profiles by establishing a gene expression profile for each of the reference samples individually; c) clustering the individual reference profiles according to similarity; and d) assigning an AML class to each cluster. The invention further relates to a method for classifying the AML of an AML-affected subject, to a method for diagnosing AML in a subject, and to a method of determining the prognosis for an AML-affected subject.
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