DIOXAPHOSPHORINANE DERIVATIVE, ITS ADDITION SALT AND SPHINGOSINE-1-PHOSPHORIC ACID (S1P1, S1P4) RECEPTOR AGONIST

摘要

PROBLEM TO BE SOLVED: To provide a dioxaphosphorinane derivative that has weak agonist actions on S1P₃ and excellent agonist actions on S1P₁ and S1P₄ receptors while hardly causing side effects.;SOLUTION: The compound having excellent agonist actions on S1P₁ and S1P₄ receptors is the dioxaphosphorinane derivative represented by general formula (1). A concrete example is 5-amino-5-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]propyl-2-hydroxy-1,3,2-dioxaphosphorinane-2-oxide.;COPYRIGHT: (C)2007,JPO&INPIT