Deficiency mutation of the production mannered null YPS1 gene and the YPS3 gene of the transformation yeast and

摘要

New satsukaromisesu serebishie variant in order to produce the human parathyroid hormone is offered. New stocks have collapsed genetics the Yap thin 1, Yap thin 2 and in at least one of the gene which encodes the protease of the Yap thin family of Yap thin 3, it has possessed the human parathyroid hormone in that genome. At high yield complete hPTH is secreted to the culture nutrient medium by culturing new stocks.