LOCALLY DOSED TYPE CONTROLLED-RELEASE IN-VIVO DEGRADABLE/ABSORBABLE MEDICAL MATERIAL

摘要

PROBLEM TO BE SOLVED: To provide a locally dosed type controlled-release preparation carrier by solving problems of a conventional locally dosed type controlled-release preparation such as the non-biodegradability and the difficulty in the control of time for hardening.;SOLUTION: The locally dosed type controlled-release in-vivo degradable/absorbable medical material has biodegradable high polymers as a base material, and an organic acid derivative as a cross-linking agent, and a medicament is included in the carrier with characteristics adaptable for the local dosing by a syringe, etc. The time for hardening and the physicochemical characteristics of the medical material can be controlled by changing the kind and concentration of the base material and the carrier, the kind and concentration of a solvent such as a phosphate buffering solution used in solving the base material, and the kind and concentration of the cross-linking agent made of the organic acid derivative.;COPYRIGHT: (C)2007,JPO&INPIT