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2-mercapto-pyridine-N-oxide derivative / oxovanadium (IV) complex

机译:2-巯基吡啶-N-氧化物衍生物/氧钒(IV)络合物

摘要

PROBLEM TO BE SOLVED: To obtain an oxovanadium (IV) complex which has an insulin-like action and is useful as a medicine for treating diabetes, hypertension, and the like, by adding a mercapto-pyridine-oxide (derivative) as a ligand. ;SOLUTION: This oxovanadium (IV) complex containing a 2-mercapto- pyridine-N-oxide (derivative) as a ligand. The 2-mercapto-pyridine-N-oxide (derivative) is preferably a ligand of the formula [R1 to R4 are each hydrogen, a (substituted) hydrocarbon, a halogen, an alkoxy, a (substituted) amino or a (substituted) heterocyclic group]. A method for producing the oxovanadium (IV) complex includes a method comprising adding an oxovanadium sulfate solution to a solution of the target ligand and then isolating the formed oxovanadium (IV) complex. A medicinal composition contains the oxovanadium (IV) complex as an active ingredient.;COPYRIGHT: (C)2000,JPO
机译:解决的问题:通过添加巯基吡啶氧化物(衍生物)作为配体,获得具有胰岛素样作用并可用作治疗糖尿病,高血压等的氧杂钒(IV)复合物。 ;解决方案:这种氧钒(IV)络合物包含2-巯基吡啶-N-氧化物(衍生物)作为配体。 2-巯基吡啶-N-氧化物(衍生物)优选为式[R 1至R 4的配体,分别为氢,(取代的)烃,卤素,烷氧基,(取代的)氨基或(取代的)杂环基]。制备氧钒钒(IV)配合物的方法包括以下方法:将硫酸氧钒钒溶液添加到目标配体的溶液中,然后分离形成的氧钒钒(IV)配合物。一种药物组合物,其包含氧杂钒(IV)复合物作为有效成分。;版权所有:(C)2000,JPO

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