1 amino acid mutation protein and that mutation cell, and those use null wild

摘要

PROBLEM TO BE SOLVED: To provide a new yeast cell strain having a new acquired character without directly operating a gene encoded by a genom DNA or its transcription product by introducing a single amino acid mutation to histone H3 or H4 and provide the use of the strain.;SOLUTION: The invention relates to a mutant yeast cell expressing a mutant histone H3 protein or histone H4 protein having a specific single amino acid residue substituted with alanine residue, a mutant histone protein of the cell, a polynucleotide encoding the mutant protein and a method for using the cell, protein and polynucleotide.;COPYRIGHT: (C)2006,JPO&NCIPI