The liver disease or method of detection of chronic glenoid riumachi and quantitative change of the heparan sulfuric acid in

摘要

PROBLEM TO BE SOLVED: To provide a means which detects a liver disease or chronic rheumatism by a method wherein a heparan sulfate in a blood sample is quantitatively determined by a simple and precise quantitative determination method for the heparan sulfate in the sample. ;SOLUTION: A detecting method in which a liver disease or chronic rheumatism can be detected is provided in such a way that, in the liver disease and the chronic rheumatism, the generation of quantitative and/or qualitative changes in a heparan sulfate in a blood sample is detected and that the changes are quantitatively determined by a quantitative determination method. In addition, a diagnostic kit which uses the method is provided. As the 'quantitative and/or qualitative changes in the heparan sulfate', e.g. a change in the amount of a specific heparan sulfate in which any residual group of sugar constituting a heparan sulfate is modified in any way, a change in molecular weight, a change in the amount of a sulfate group, a change in the amount of a heparan sulfate having a sulfate group or the like is enumerated.;COPYRIGHT: (C)1999,JPO