Genome involved in rheumatoid arthritis, diagnostic method thereof, determination method of its onset, diagnostic kit for detection thereof, therapeutic method and therapeutic agent for rheumatoid arthritis

摘要

Mutations in a genome associating in rheumatoid arthritis (RA) are found in human DR3 genomic DNA having the base sequence represented by SEQ ID NO:1. The invention provides a genome having such mutations, transcripts thereof, a method of highly accurately evaluating the RA onset or the RA onset possibility by using the mutations thereof, an evaluation kit therefor, and a therapeutic method and remedies for RA.