Genomes participating in rheumatoid arthritis, method of the diagnosis thereof, method of evaluating the onset possibility thereof, diagnostic kit for detecting them and therapeutic method and remedies for rheumatoid arthritis

摘要

Mutations in a genome associating in rheumatoid arthritis (RA) are found in human DR3 genomic DNA having the base sequence represented by SEQ ID NO:1. The invention provides a genome having such mutations, transcripts thereof, a method of highly accurately evaluating the RA onset or the RA onset possibility by using the mutations thereof, an evaluation kit therefor, and a therapeutic method and remedies for RA.