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Recombinant protein of Pakistani strain of hepatitis E and its diagnostic method and use in seed pods
Recombinant protein of Pakistani strain of hepatitis E and its diagnostic method and use in seed pods
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机译:巴基斯坦戊型肝炎病毒株的重组蛋白及其诊断方法和在种子荚中的应用
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摘要
A strain of hepatitis E virus from Pakistan (SAR-55) implicated in an epidemic of enterically transmitted non-A, non-B hepatitis, now called hepatitis E, is disclosed. The invention relates to the expression of the whole structural region of SAR-55, designated open reading frame 2 (ORF-2), in a eukaryotic expression system. The expressed protein is capable of forming HEV virus-like particles which can serve as an antigen in diagnostic immunoassays and as an immunogen or vaccine to protect against infection by hepatitis E.
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