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Antagonizing TGF-beta activity with various ectodomains of TGF-beta receptors used in combination or as fusion proteins
Antagonizing TGF-beta activity with various ectodomains of TGF-beta receptors used in combination or as fusion proteins
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机译:与TGF-β受体的各种胞外域结合或作为融合蛋白拮抗TGF-β活性
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摘要
Anti-cancer agents and/or transforming growth factor beta (TGF-beta or TGFβ) antagonists are disclosed, where the agents and/or antagonists include a therapeutically effective amount of a combination of therapeutically active portions of sRII and therapeutically active portions of sRIII or a fusion polypeptide or protein comprising therapeutically active portions of sRII and therapeutically active portions of sRIII. Methods for preventing, treating and/or ameliorating the symptoms of cancer are also disclosed based on administering an effective amount of a composition of this invention.
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