首页>
外国专利>
Indole-containing compounds with anti-tubulin and vascular targeting activity
Indole-containing compounds with anti-tubulin and vascular targeting activity
展开▼
机译:具有抗微管蛋白和血管靶向活性的含吲哚的化合物
展开▼
页面导航
摘要
著录项
相似文献
摘要
Trimethoxyphenyl substituted indole ligands have been discovered which demonstrate impressive cytotoxicity as well as a remarkable ability to inhibit tubulin assembly. Such compounds as well as related derivatives are excellent clinical candidates for the treatment of cancer in humans. In addition, certain of these ligands, as pro-drugs, may well prove to be tumor selective vascular targeting chemotherapeutic agents or to have vascular targeting activity resulting in the selective prevention and/or destruction of nonmalignant proliferating vasculature.
展开▼