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Methods for the identification of agents for the treatment of seizures, neurological diseases, endocrinopathies and hormonal diseases
Methods for the identification of agents for the treatment of seizures, neurological diseases, endocrinopathies and hormonal diseases
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机译:鉴定治疗癫痫,神经系统疾病,内分泌病变和激素疾病的药物的方法
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摘要
The present invention is drawn to methods of characterization of the properties and functions of SV2 proteins. The invention further includes methods of identifying compounds or agents which modulate the activity of SV2 proteins. Included in these methods is the identification of compounds or agents which modulate the binding of levetiracetam to SV2 proteins, including SV2A. Additionally, the present invention provides biotinylated ligands as a tool to screen chemical libraries and characterize the SV2 proteins. Further, the present invention provides a method of solubilizing and purifying functionally active membrane associated proteins, such as SV2.
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