Method and system of verifying protein-protein interaction using protein homology relationship

摘要

Provided are a method and system for verifying a protein-protein interaction of a species by using a homology relationship between proteins of the species and proteins of other species. The method includes generating one or more protein homology relationships between source proteins of a species and heterogeneous proteins of one or more other species, generating one or more heterogeneous protein interactions corresponding to a specific source protein interaction using the generated one or more protein homology relationships, and determining whether the generated one or more heterogeneous protein interactions are present between the heterogeneous proteins of one or more species. Accordingly, a protein-protein interaction of a specific high-rank organism can be automatically verified by using protein-protein interactions of a low-rank organism that can be easily determined at low costs, without an expensive biological experiment.