Modulation of Epac, phospholipase Cepsilon, and phospholipase D to treat pain

摘要

The present invention provides methods, compositions, and kits useful for reducing pain in a subject by inhibiting Epac, PLCε, and/or PLD. In addition, the invention provides a variety of prescreening and screening methods aimed at identifying agents that reduce pain. Methods of the invention can involve assaying test agent binding to Epac, PLCε, or PLD. Alternatively, test agents can be screened for their ability to alter the level of Epac, PLCε, or PLD polypeptides, polynucleotides, or action.