Novel inhibitor of angiogenesis, tumor progression, and metastasis targeting ras signalling pathway

摘要

The present invention relates to a novel use of thymosin β₁₀ protein for anti-angiogenesis, anti-tumor progression, and anti-metastasis by targeting a Ras signaling pathway. Particularly, thymosin β₁₀ protein reduces the generation of a Ras-GTP/Raf complex by sequestering Ras-GTP or by interfering with the binding of Ras-GTP to Raf through a direct interaction with Ras, resulting in the inhibition of autocrine and paracrine production of VEGF. Therefore, thymosin β₁₀ protein of the present invention can be effectively used to treat disease conditions associated with angiogenesis, tumor progression, and/or metastasis, particularly those caused by the activation of the Ras signaling pathway, such as solid tumors, rheumatoid arthritis, psoriasis, and diabetic retinopathy.