Biosynthesis of bryostatins by polyketide synthases (PKS)

摘要

The present invention relates to the discovery, isolation and sequencing of novel polyketide synthase genes. These newly identified genes are involved in the biosynthesis of bryostatins. The genes are found to be expressed in all life stages of Bugula neritina, are associated with the bacterial symbiont Endobugula sertula and are believed to be part of a large polyketide gene cluster that is responsible for the production of bryostatins.