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Method of modulating smooth muscle cell functioning by modulating sphingosine kinase mediated signalling
Method of modulating smooth muscle cell functioning by modulating sphingosine kinase mediated signalling
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机译:通过调节鞘氨醇激酶介导的信号传导调节平滑肌细胞功能的方法
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摘要
The present invention relates generally to a method of modulating smooth muscle cell functioning and agents useful for same. More particularly, the present invention relates to a method of modulating smooth muscle tone by modulating intracellular sphingosine kinase mediated signalling. The method of the present invention is useful, inter alia, in the treatment and/or prophylaxis of conditions characterised by aberrant, unwanted or otherwise inappropriate smooth muscle tone, in particular aberrant, unwanted or otherwise inappropriate vascular, bronchial or intestinal smooth muscle tone.
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