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Yeast transformant producing recombinant human parathyroid hormone and method for producing the hormone
Yeast transformant producing recombinant human parathyroid hormone and method for producing the hormone
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机译:产生酵母转化体的重组人甲状旁腺激素及其生产方法
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摘要
Novel Saccharomyces Cerevisiae mutant strains are provided for producing human parathyroid hormone. The novel strains acre genetically disrupted in at least one of the genes encoding the yapsin family of proteases Yapsin 1, Yapsin 2 and Yapsin 3 and harbor a human parathyroid hormone gene in their genomes. Culturing the novel strains results in the secretion of intact hPTH into culture media at high yield.
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