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YEAST TRANSFORMANT PRODUCING RECOMBINANT HUMAN PARATHYROID HORMONE AND METHOD FOR PRODUCING THE HORMONE
YEAST TRANSFORMANT PRODUCING RECOMBINANT HUMAN PARATHYROID HORMONE AND METHOD FOR PRODUCING THE HORMONE
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机译:酵母转化子生产重组人副甲状腺激素和生产该激素的方法
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摘要
Novel Saccharomyces Cerevisiae mutant strains are provided for producing human parathyroid hormone. The novel strains are genetically disrupted in at least one of the genes encoding the yapsin family of proteases Yapsin 1, Yapsin 2 and Yapsin 3 and harbor a human parathyroid hormone gene in their genomes. Culturing the novel strains results in the secretion of intact hPTH into culture media at high yield.
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