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Mid-life vaccine and methods for boosting anti-mycobacterial immunity
Mid-life vaccine and methods for boosting anti-mycobacterial immunity
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机译:中年疫苗和增强抗分枝杆菌免疫力的方法
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摘要
Vaccine compositions for boosting immunity to mycobacteria when administered in mid-life in a subject who has been vaccinated neonatally or in early childhood with BCG and in whom protective immunity has waned comprise one or more purified immunogenic proteins from Mycobacterium tuberculosis from a group of 30 proteins that stimulate T cell immunity and interferon-γ secretion. A preferred protein is Ag85A, the secreted product (SEQ ID NO:31) of the Rv3084c gene. Also disclosed are methods for boosting immunity in such BCG-vaccinated subjects comprising administering an effective amount of the above vaccine composition.
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机译:在新生儿或儿童早期接种过BCG且其保护性免疫力减弱的对象中年中给药时,用于增强分枝杆菌免疫力的疫苗组合物包含一种或多种来自结核分枝杆菌 I的纯化免疫原性蛋白>选自刺激T细胞免疫和干扰素-γ分泌的30种蛋白质。优选的蛋白质是Ag85A,Rv3084c基因的分泌产物(SEQ ID NO:31)。还公开了在这种BCG疫苗接种的受试者中增强免疫力的方法,包括施用有效量的上述疫苗组合物。
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