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Novel n-substituted 2-aminopyridine derivatives

机译:新的n-取代的2-氨基吡啶衍生物

摘要

There are provided novel compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R17, L1, L2, L3 and Q are as defined in the specification, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of nitric oxide synthase and are thereby particularly useful in the treatment or prophylaxis of inflammatory disease and pain. embedded image
机译:提供了式(I)的新型化合物,其中R 1 ,R 2 ,R 3 ,R 4 ,R 5 ,R 6 ,R 7 ,R 8 ,R 9 ,R 17 ,L 1 ,L 2 ,L 3 和Q如规范中所定义其药学上可接受的盐;连同其制备方法,包含它们的组合物及其在治疗中的用途。该化合物是一氧化氮合酶的抑制剂,因此特别用于治疗或预防炎症性疾病和疼痛。 <图像alt =“嵌入式图像” file =“ US20060270714A1-20061130-C00001.GIF” he =“ 33.19mm” imgContent =“ chem” imgFormat =“ GIF” wi =“ 69.85mm“ />

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