Methods and systems for simulating multi-phase fluid flows, including fire suppressant flows, are disclosed. A method in accordance with one embodiment of the invention includes estimating flow properties of a multi-phase flow at a boundary of a volume and, based on the estimate of flow properties at the volume boundary, at least estimating a value for a quality of the multi-phase flow at the volume boundary. Based on the quality of the flow and the flow properties, the method can further include at least estimating a value for a liquid phase droplet velocity of a liquid phase portion of the flow, and based on the liquid phase droplet velocity, simulating characteristics of the flow into the volume. Accordingly, the method can be used to predict constituent concentrations in the volume, for example, concentrations of a fire suppressant in an aircraft engine compartment.
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