首页> 外国专利> Method of analyzing non-complexed forms of prostate specific antigen in a sample to improve prostate cancer detection

Method of analyzing non-complexed forms of prostate specific antigen in a sample to improve prostate cancer detection

机译:分析样品中非复杂形式的前列腺特异性抗原以改善前列腺癌检测的方法

摘要

Assays for detecting and determining the presence of prostate cancer is provided. The assays are capable of detecting prostate cancer in the population of men with a significantly higher ratio of free PSA to total PSA. The assays are also capable of detecting prostate cancer in the population of men with a low amount of total PSA, i.e., in the range of 2 to 4 ng/ml. In accordance with one embodiment of the present invention, the assay includes the steps of (a) determining the amount of total PSA contained in a biological sample from the patient, (b) determining the amount of free PSA in the sample; and calculating the ratio of the free PSA to the total PSA, (c) determining the amount of pPSA in the sample, (d) determining the amount of BPSA in the sample, (e) determining the amount of inPSA in the sample, and (f) correlating the amount of inPSA contained in the sample to the presence of prostate cancer in the patient by comparing the amount of inPSA to a predetermined value established with control samples of known cancer and benign disease diagnosis, based on both the level of total PSA and the % free PSA.
机译:提供了用于检测和确定前列腺癌的存在的测定法。该测定法能够检测游离PSA与总PSA比例明显更高的男性人群中的前列腺癌。该测定法还能够在总PSA量低,即在2-4ng / ml范围内的男性人群中检测前列腺癌。根据本发明的一个实施方案,该测定包括以下步骤:(a)确定来自患者的生物样品中所含的总PSA的量,(b)确定样品中的游离PSA的量;以及计算游离PSA与总PSA的比率,(c)确定样品中pPSA的量,(d)确定样品中BPSA的量,(e)确定样品中inPSA的量,以及(f)通过将inPSA的量与由已知癌症和良性疾病诊断的对照样品确定的预定值进行比较,基于总水平,将样品中所含的inPSA量与患者中前列腺癌的存在相关联PSA和%的免费PSA。

著录项

相似文献

  • 专利
  • 外文文献
  • 中文文献
获取专利

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号