首页> 外国专利> Methods for producing and using in vivo pseudotyped retroviruses using envelope glycoproteins from lymphocytic choriomeningitis virus (LCMV)

Methods for producing and using in vivo pseudotyped retroviruses using envelope glycoproteins from lymphocytic choriomeningitis virus (LCMV)

机译：使用来自淋巴细胞性脉络膜脑膜炎病毒（LCMV）的包膜糖蛋白生产和使用体内假型逆转录病毒的方法

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摘要

The present invention provides novel pseudotyped retroviral vectors that can transduce human and other cells. Vectors are provided that are packaged efficiently in packaging cells and cell lines to generate high titer recombinant virus stocks expressing novel envelope glycoproteins. The present invention further relates to compositions for gene therapy. 展开▼

机译：本发明提供了可以转导人和其他细胞的新型假型逆转录病毒载体。提供了有效包装在包装细胞和细胞系中的载体，以产生表达新型包膜糖蛋白的高滴度重组病毒原种。本发明进一步涉及用于基因治疗的组合物。展开▼

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公开/公告号US7160727B2

专利类型

公开/公告日2007-01-09

原文格式PDF

申请/专利权人 PAUL B. MCCRAY JR.;BEVERLY L. DAVIDSON;COLLEEN STEIN;
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申请/专利号US20040993319

发明设计人 COLLEEN STEIN;BEVERLY L. DAVIDSON;PAUL B. MCCRAY JR.;
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申请日2004-11-19

分类号C12N15/867;C12N15/63;C12N15/64;A61K48/00;

国家 US

入库时间 2022-08-21 20:59:47

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3. Methods for producing and using in vivo pseudotyped retroviruses using envelope glycoproteins from lymphocytic choriomeningitis virus (LCMV) [P] . 美国专利： US7931893B2 . 2011-04-26

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