An isolated DNA fragment of the Human promoter of SPARC and its use to direct the expression of a heterologous Gene in tumor cells

摘要

The isolated DNA sequence from 513 to 35 substrates is a region of the human initiator of the SPRC gene, which can guide the expression of heterogeneous genes of interest, which may be related to any other promoter sequence, such as radiation response sequence, hypoxia and free matrix. The structure and viral vector of recombinant DNA virus expression are provided, including gene sequence separated from human initiator of SPRC gene and at least one operable gene related to it,The promoter sequence results in the expression of at least one rectal gene in tumor cells. There are pharmaceutical ingredients and methods of treating tumors.