Use of Estradiol Valerate in combination with Dienogest for oral Therapy of dysfunctional uterine Bleeding with a Combined Oral Contraception

摘要

Is the use of Estradiol Valerate in combination with 17alfa cyanomethyl - 17 - beta - hidroxiestra - 4.9 - dien - 3-one (MEN) to produce a POLYPHASE combined preparation for the oral Therapy of dysfunctional uterine bleeding in combination with oral Contraception.The combination of Estradiol Valerate with Dienogest includes in this case a first phase of 2 units of daily doses of 3 mg of Estradiol Valerate or estradiol less than 3 mg, a Second Phase of 2 groups of units Daily dosesWhere the first group contains 5 units of daily doses of a combination of 2 mg estradiol or Estradiol Valerate below 2mg and 2 mg Dienogest and the second group contains 17 units of daily doses of a combination of 2 mg estradiol or Estradiol Valerate and below 2mg 3 mg Dienogest,A third phase of 2 units with daily doses of 1 mg of Estradiol Valerate or lower estradiol 1 mg phase and another 2 units of pharmaceutically Safe Daily doses of placebo. All units of daily doses of the combination and placebo polyphasic pharmaceutically innocuous correspond to 28 days.The duration and the application comprises at least one cycle depends on the intake and individual desire of women to Contraception.