method of eliciting a t-cell response against a t-cell epitope in a mammalian host individual, assay for testing the effectiveness of a method of eliciting a t-cell response, and kit for performing them

摘要

"METHOD OF ELICATING A T-CELL RESPONSE AGAINST A T-CELL EPYPE IN A MAMMALIAN HOST GUEST TEST TO TEST THE EFFECTIVENESS OF A T-CELL RESPONSE," KITES TO REAL. The invention relates to a method of eliciting a T cell response against a T cell epitope in a host mammalian subject, which method comprises: (i) a first immunization comprising at least two administrations, which are from 1 to 14 separate days in the individual, wherein each administration comprises administering a nucleotide of interest (NOI) encoding the T cell epitope and optionally (ii) a second immunization comprising at least one administration to the individual of (a) a NOI encoding the T cell epitope or (b) a protein comprising the T cell epitope, wherein the time between the first administration of the first immunization and the first administration of the second immunization is 21 to 365 days.